(A) Schematic diagram of the experimental system that detects calcium release from the endoplasmic reticulum by each ryanodine receptor. (B) Isoflurane selectively activates RyR1 (mean ± standard ...

Since their anesthetic effects were discovered approximately 180 years ago, inhalational anesthetics have been used for general anesthesia in surgical operations. However, the mechanism of their ...

Not many drugs are as widely used yet poorly understood as anesthetics. “We’ve used them for over a century, but nobody understands how they work,” says Alex Proekt, an anesthesiologist and ...