Homologous recombination is a DNA repair mechanism that counteracts double-stranded breaks in DNA. Researchers at Kindai University have recently revealed how the Sae2 protein coordinates with the ...

DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision repair, ...

When an SSB appears, polymerase epsilon approaches the nick before retracing its steps thanks to its exonuclease, allowing fork reversal to take place. The nick is repaired as an SSB, and replication ...

Deinococcus radiodurans is renowned for its extraordinary resistance to ionising radiation and other environmental stresses. This bacterium employs a combination of passive and active mechanisms to ...

"Use it or lose it" goes the adage, applied liberally to everything from our muscles to our minds, especially as we age. Yet when it comes to the brain, such usage is not entirely a good thing: While ...

Researchers have uncovered how specific DNA rearrangements called inverted triplications contribute to the development of various genetic diseases. The study reveals that during DNA repair, segments ...

One of the biggest challenges in cancer treatment is chemoresistance: Tumors that initially respond well to chemotherapy become resistant over time. When that happens, treatment options are often ...

A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA. Published online May 16 in the journal Cell, the report describes the ...

A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for improving cancer treatment outcomes. The result was published in Cell Death & ...

How an enzyme involved in DNA repair becomes vital to the survival of certain cancers has been identified by scientists, paving the way for clinical trials evaluating the effects of blocking this ...